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Chronic fatigue review: Feeling fatigued occasionally is a normal part of life, often attributed to a lack of sleep, physical exertion, or stress. However, when fatigue becomes persistent and begins to interfere with daily activities, it may indicate an underlying medical condition. Chronic fatigue, characterized by profound tiredness that doesn’t improve with rest, can significantly impact one’s quality of life. In this article, we delve into the various factors contributing to chronic fatigue, its symptoms, and potential treatment options.

Causes of Chronic Fatigue Review:

1.Medical Conditions

Chronic fatigue can be a symptom of numerous medical conditions, including:

  • Thyroid Disorders: Hypothyroidism (underactive thyroid) can lead to fatigue due to a decrease in thyroid hormone production.
  • Anemia: Iron deficiency anemia, characterized by low red blood cell count, can result in decreased oxygen delivery to tissues, leading to fatigue.
  • Chronic Fatigue Syndrome (CFS): Also known as myalgic encephalomyelitis (ME), CFS is a complex disorder characterized by extreme fatigue that lasts for at least six months and is not relieved by rest.
  • Autoimmune Diseases: Conditions such as lupus, rheumatoid arthritis, and multiple sclerosis can cause fatigue due to the body’s immune system attacking its tissues.
  • Sleep Disorders: Conditions like sleep apnea, insomnia, and restless leg syndrome can disrupt sleep patterns, leading to chronic fatigue.
  • Depression and Anxiety: Mental health disorders can manifest with physical symptoms, including fatigue.
  • Medications: Certain medications, including antihistamines, antidepressants, and opioids, can cause drowsiness and fatigue as side effects.

2. Lifestyle Factors

Certain lifestyle choices can contribute to chronic fatigue, such as:

  • Poor Diet: Inadequate intake of nutrients, dehydration, and excessive consumption of caffeine or sugar can lead to fatigue.
  • Lack of Exercise: Sedentary lifestyles can result in decreased energy levels and increased fatigue.
  • Stress: Chronic stress can lead to fatigue by exhausting the body’s resources and disrupting sleep patterns.


The primary symptom of chronic fatigue is persistent tiredness that doesn’t improve with rest. Other common symptoms may include:

  • Muscle or joint pain
  • Headaches
  • Memory and concentration difficulties (often referred to as “brain fog”)
  • Sore throat
  • Enlarged lymph nodes
  • Unrefreshing sleep
  • Post-exertional malaise (worsening of symptoms after physical or mental exertion)

Treatment of Chronic Fatigue

Treating chronic fatigue often involves addressing underlying medical conditions and making lifestyle changes. Treatment strategies may include:

  • Medical Management: Depending on the underlying cause, treatment may involve medications such as thyroid hormone replacement for hypothyroidism, iron supplementation for anemia, or antidepressants for depression.
  • Cognitive Behavioral Therapy (CBT): CBT can be helpful in managing symptoms of chronic fatigue by addressing negative thought patterns and promoting coping strategies.
  • Graded Exercise Therapy (GET): GET involves gradually increasing physical activity levels under the guidance of a healthcare professional to improve stamina and reduce fatigue.
  • Sleep Hygiene: Practicing good sleep habits, such as maintaining a regular sleep schedule, creating a relaxing bedtime routine, and ensuring a comfortable sleep environment, can help improve sleep quality.
  • Nutrition and Hydration: Eating a balanced diet rich in fruits, vegetables, lean proteins, and whole grains, and staying hydrated can help combat fatigue.
  • Stress Management: Techniques such as mindfulness meditation, yoga, deep breathing exercises, and relaxation techniques can help reduce stress and improve overall well-being.


Chronic fatigue is a complex condition with various underlying causes, ranging from medical conditions to lifestyle factors. Identifying and addressing the root cause of fatigue is essential for effective management. If you’re experiencing persistent fatigue, it’s crucial to consult with a healthcare professional for proper evaluation and personalized treatment recommendations. With the right approach, chronic fatigue can be managed, and quality of life can be significantly improved.

For more of the latest research on chronic fatigue, read Latest Research and Reviews of “Nature Portfolio”.

Disclaimer: As a service to our readers, MVS Pharma GmbH publishing provides access to our library of archived content — in our blog. Please note the date of last review or update on all articles. No content on this site, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

Dr. Disha Trivedi

Dr. Disha Trivedi is PhD in Molecular Genetics and Biotechnology. She is working as a medical writer and researcher at MVS Pharma GmbH.