*Information last updated on 12.12.2024
Fat deposition is a major health concern in modern society, and the rise in sedentary lifestyles, poor eating habits, and increased stress levels have all contributed to this issue. With many medications and quick-fix solutions available, it can be confusing for people to figure out the most effective and sustainable way to address fat deposition without putting their long-term health at risk. While there are medications and weight loss drugs that claim to help with fat reduction, many come with potential side effects, especially when used long-term. In some cases, medications or even surgery (like bariatric surgery) might be appropriate for individuals who have severe obesity and are at risk for serious health complications.
Hesperidin is a promising natural compound with potential benefits for fat reduction, improved metabolism, and overall health. Hesperidin may enhance fat oxidation, which is the process by which the body breaks down fat to use for energy. Some studies suggest that hesperidin can promote the breakdown of stored fat and its conversion into energy, thus contributing to fat loss over time. Hesperidin’s potential to help regulate appetite and satiety, along with its effects on fat metabolism, makes it a promising natural compound for supporting weight management.
Hesperidin, which is predominantly found in the white pith of citrus fruits, particularly grapefruit, may play a role in fat loss through several mechanisms. So the better solution is hesperidin combined with proper exercise may help enhance fat loss by supporting metabolic processes, improving fat burning, and regulating factors such as appetite and insulin sensitivity.
A hesperidin supplement typically contains hesperidin as the main active ingredient. along with a variety of other ingredients designed to enhance absorption, improve bioavailability, and support the overall health benefits of the supplement. These may include bioavailability enhancers like piperine, vitamin C, and fatty acids, as well as other antioxidants or anti-inflammatory compounds.
hesperidin inhibits the expression of lipogenic enzymes such as fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), both of which are involved in fat synthesis. By suppressing these enzymes, hesperidin may reduce the formation of new fat stores in the body. Some studies suggest that hesperidin inhibits the expression of lipogenic enzymes such as fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), both of which are involved in fat synthesis. By suppressing these enzymes, hesperidin may reduce the formation of new fat stores in the body. Hesperidin’s potential to promote fat oxidation (the burning of fat for energy) is another important mechanism for fat reduction.
Hesperidin is indeed a bioflavonoid with several significant health benefits. The name hesperidin is derived from “hesperidium”.The botanical term for the type of fruit produced by citrus trees. The hesperidium is a specific type of berry with a leathery rind, characteristic of citrus fruits like oranges, lemons, and grapefruits. Hesperidin was first isolated in 1828 by French chemist M. Lebreton from the white inner layer of citrus peels.
Hesperidin content in citrus fruits, according to the review by Gattuso et al., varies depending on the type of citrus fruit and the part of the fruit being used. The highest concentrations of hesperidin are found in the peel, particularly in the flavedo (the colored outer layer) and albedo (the white, soft middle layer part of the peel). These parts of the citrus fruit contain significantly higher amounts of hesperidin compared to the juice extracted from the fruit. The peel contains more hesperidin because the flavedo and albedo are the parts of the citrus fruit that play a protective role for the fruit itself. They help to protect the fruit from environmental stresses and pathogens, and they store a large portion of the bioactive compounds, including flavonoids like hesperidin, which may contribute to the fruit’s antioxidant and anti-inflammatory properties. For those who don’t want to consume citrus peel directly, hesperidin supplements derived from citrus peel are available. These supplements typically provide a concentrated dose of the flavonoid, making it easier to get higher levels of hesperidin without having to eat large quantities of citrus. While hesperidin has garnered attention for its potential role in weight reduction and fat metabolism, it offers a wide range of other health benefits as well.
Antioxidant, anti-inflammatory, gut health, neuroprotective health, etc. One of the major drawbacks of hesperidin is its bioavailability—that is, its ability to be absorbed and utilized effectively by the body. While hesperidin is a potent bioflavonoid with numerous health benefits, it is poorly absorbed when taken orally in its natural form. This is a common issue for many flavonoids and polyphenols. However, as you pointed out, there are several strategies and technologies available to enhance its absorption and increase its effectiveness in the body. The issue can be effectively addressed using various technological advancements and natural enhancers. Methods like micro ionization, the use of absorption enhancers (such as piperine and fats), encapsulation techniques, fermentation, and combination with other bioactive compounds have all been shown to improve their bioavailability.
By utilizing these methods, the body is able to absorb and utilize hesperidin more effectively, enhancing its health benefits, including its cardioprotective, anti-inflammatory, antioxidant, and weight management effects. Therefore, while hesperidin’s absorption may initially seem like a limitation, modern approaches have provided solutions to make this valuable flavonoid more accessible to the body.
Quoting our biologist, with a PhD in natural sciences, Eva Kuennemann “As far as I know, there is no herbal drug hesperidin on the market from competitors. As food supplement hesperidin is sold, however, the products that are currently on the market contain raw materials with questionable purity and also bioavailability.”
No Side Effects: As a natural compound, it is well-tolerated, non-toxic, and safe for long-term use.
Enhanced Bioavailability: Our innovative formulation ensures optimal absorption and bioavailability of Hesperidin Formulation, maximizing its effectiveness in providing robust antivirus protection.
Sustainable and Environmentally Friendly: At MVS Pharma GmbH, we are committed to sustainability and environmental stewardship. Hesperidin Formulation is sourced from responsibly grown citrus fruits, ensuring minimal ecological impact.
Trusted and Validated: Hesperidin Formulation has undergone rigorous testing and preclinical trials to establish its efficacy as a natural antivirus solution. The results have been overwhelmingly positive, confirming its ability to combat viral infections effectively.
The typical dosage range for hesperidin used in supplements is generally between 500 mg and 1,000 mg per day for general health benefits, with the potential for higher doses (up to 1,500 mg per day) for specific purposes like fat reduction, metabolic support, or cardiovascular health. Here’s a more detailed breakdown of recommended dosages.
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100% natural substances
Enhanced Biovailability
Trusted and Validated
The supplement development process involves several stages, from initial research and formulation to manufacturing and distribution.Read all about our Quality check and management processes.
The process begins with identifying a need or a target market for a new supplement. This can be based on scientific research, market trends, consumer demands, or existing gaps in the market.
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