The mechanism of action of Salbutamol depends on its composition. The active ingredient Salbutamol is one of the best-known representatives of the so-called beta-sympathomimetics. It expands the bronchi and is therefore used to treat asthma, chronic bronchitis, and COPD, among other symptoms of the lung. The person can breathe more easily again. The effect of Salbutamol sets in quickly but does not last long. The drug is usually administered by inhalation (powder inhaler, pressurized gas inhalation, inhalation solution for nebulization), with the effect occurring after 5–15 minutes.
What is the Detailed Action of Salbutamol?
The human body has an autonomic nervous system that is not voluntarily controllable. It consists of two parts that behave like counterparts to each other: the parasympathetic nervous system and the sympathetic nervous system. If the parasympathetic system has the upper hand, the heartbeat slows down, digestion is stimulated and basic muscle tension decreases. Doctors speak of the “rest-and-digest” reaction.
On the other hand, when the sympathetic nervous system is activated, the body is prepared for performance in the sense of the “fight-or-flight” reaction. The heartbeat becomes faster, the pupils dilate, and digestive activity is slowed down. In addition, the bronchi are widened to the maximum to enable good gas exchange and thus provide sufficient oxygen for cellular respiration. This stress reaction is mediated by the messenger substances adrenaline and norepinephrine. The mechanism of action of Salbutamol is to mimic the effect of these stress hormones in the lungs and cause the bronchi to dilate, thereby improving the uptake of oxygen and the release of carbon dioxide. The active ingredient quickly has a selective effect on the lungs.
Salbutamol is a so-called β2-agonist, which means it binds to β2-adrenergic receptors on bronchial smooth muscle cells to cause smooth muscle relaxation. This is done in several steps. When the molecule binds to the receptor, cAMP is produced, which subsequently leads to a reduction of the calcium concentration in the cells, which in turn leads to relaxation of the smooth muscles and thereby to bronchodilation.
When and how often should you use Salbutamol?
Salbutamol is used as an emergency medication and is only applied when needed. If sudden breathing difficulties occur, a single puff of the inhaler is usually used. The effect of Salbutamol can sometimes occur within a few seconds.
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MVS Pharma GmbH will soon be launching an omega-3 dietary supplement onto the European market that has been developed for the highest quality standards in terms of oxidation avoidance and therefore greatest bioavailability. In addition, in vitro studies are currently underway at the University of Ulm, in which Professor Dr. Rüdiger Groß tested a patented mouth and nose spray (Virudol) that can eliminate various flu viruses based on natural substances. In addition, MVS has a wholesale license and has specialized in sourcing much-needed medicines such as Amoxicillin, Salbutamol, etc. from India through its local branch with a focus on local quality and safety testing, compliance with international GMP regulations and the highest quality level of user security (examples of local language brochures, identical units of measurement, batch control and full tracking, etc.).
