Published: Heart International, Vol. 2 No. 2, 2006 | Overview of the study created and cited by MVS Pharma GmbH
Scientific Summary
Introduction: Why Cardiovascular Health Still Demands Innovation
Despite decades of medical advances, cardiovascular diseases (CVD) remain the leading cause of death worldwide. Arterial hypertension is one of the most significant modifiable risk factors, with even mild blood pressure elevation increasing cardiovascular risk. While pharmaceutical treatments are available, not everyone benefits from or requires medication. As a result, dietary and lifestyle interventions — including omega-3 polyunsaturated fatty acid (PUFA) supplementation — are gaining prominence.
This review explores the biological and clinical implications of omega-3 polyunsaturated fatty acids (PUFAs), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the management of blood pressure. Widely present in fish and fish oils, these PUFAs are known to support cardiovascular health and may moderately reduce blood pressure, an effect that is increasingly relevant in light of the global hypertension burden.
At MVS Pharma GmbH, we align rigorous scientific research with advanced product development. This article reviews the clinical role of omega-3 PUFAs, their mechanisms in blood pressure management, and how these insights directly shape the formulation and quality standards behind our MVS Omega 3 capsules.
The Clinical Role of Omega-3 PUFAs in Blood Pressure Control
Omega-3 PUFAs, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are essential fatty acids primarily found in fish and fish oils. Multiple clinical studies confirm their capacity to moderately lower both systolic and diastolic blood pressure, supporting heart health in both hypertensive and normotensive individuals.
Key findings include:
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Daily omega-3 intake (2–4g) reduced blood pressure by 2–6 mmHg.
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DHA demonstrated superior blood pressure-lowering effects compared to EPA.
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Long-term fish oil use may protect against hypertension-related organ damage.
Additionally, the use of PUFA supplements has recently received a large implementation even in fields unrelated to cardiovascular diseases, such as neurology (epilepsies), psychiatry (psychosis, severe depressions), rheumatology (osteoarthritis, psoriasis), clinical immunology (allergy), gastroenterology (inflammatory bowel diseases), nephrology (autoimmune nephropathies) (i.e.: chronic renal failure, congestive heart failure).
How Omega-3 PUFAs Work: Multi-Pathway Cardiovascular Benefits
Omega-3 fatty acids lower blood pressure via several well-documented mechanisms:
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Enhancing vasodilation by boosting nitric oxide (NO) and prostaglandin I2 (PGI2) production.
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Competing with pro-inflammatory omega-6 fatty acids, reducing vasoconstrictive compounds.
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Inhibiting angiotensin-converting enzyme (ACE) activity and decreasing angiotensin II formation.
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Lowering oxidative stress markers and activating the parasympathetic nervous system.
This multifactorial action improves arterial compliance and vascular function, factors essential for long-term cardiovascular protection.
Clinical studies cited include trials with dyslipidemic, diabetic, elderly, normotensive, and hypertensive patients, showing that daily supplementation of 2–4 g of omega-3 PUFAs modestly but significantly reduces systolic and diastolic blood pressure (by ~2–6 mmHg). DHA, in particular, showed greater efficacy than EPA in lowering blood pressure and heart rate. Long-term fish oil intake may also protect against hypertension-related organ damage.
*Note: However, not all studies were consistent—differences in dosage, EPA/DHA ratios, and population characteristics impacted outcomes. The review also raises safety concerns about oxidation of PUFAs and potential contamination of fish sources with mercury or other pollutants, recommending varied and moderate intake.
MVS Omega-3: From Clinical Insight to Product Innovation
1. Optimized Bioavailability
The clinical review underlined the importance of bioavailable EPA and DHA. Many conventional supplements deliver omega-3s in ethyl ester form, limiting absorption. At MVS Pharma, we formulated MVS Omega 3 capsules using triglyceride-bound omega-3s, ensuring higher absorption and systemic efficacy.
Our in vitro and human pilot studies confirm improved absorption rates, directly correlating with better blood pressure modulation outcomes, in alignment with clinical data.
2. Advanced Oxidation Control
Omega-3 PUFAs are vulnerable to oxidation, reducing efficacy and introducing potential health risks. To address this:
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We use nitrogen flushing and low-oxygen encapsulation environments.
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Incorporate natural antioxidants like tocopherols.
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Test every batch for peroxide and anisidine values to exceed European safety thresholds.
3. Purity Without Compromise
Environmental pollutants in fish oils, such as mercury, PCBs, and dioxins, are a known concern. At MVS Pharma:
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We source omega-3s from certified sustainable fisheries.
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Use advanced molecular distillation to eliminate contaminants.
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Adhere to strict EU and GOED standards for purity and heavy metals.
4. Multifactorial Efficacy Confirmed
Building on the multi-mechanistic benefits highlighted in the review, MVS Pharma conducted:
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Endothelial function tests (flow-mediated dilation, pulse wave velocity)
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Inflammatory cytokine profiling
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Redox balance assessments
Participants using MVS Omega 3 for 8 weeks showed improvements consistent with findings from Borghi and Cicero’s work, reinforcing our evidence-based development approach.
Scientific Transparency and Quality Partnerships
We believe in open, verifiable science. MVS Pharma publishes:
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Full fatty acid profiles
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Oxidation value reports
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Purity certifications
Our raw materials and processes are independently certified by Friend of the Sea and IFOS, ensuring transparency from ocean to capsule.
Conclusion: Nature, Evidence, and Technology Combined
This review affirms the cardiovascular benefits of omega-3 PUFAs — especially DHA — in managing blood pressure. Guided by this evidence, MVS Pharma GmbH has developed a high-bioavailability, oxidation-resistant, and contaminant-free omega-3 formulation tailored for cardiovascular health.
MVS Omega 3 capsules embody our philosophy: advancing health solutions where nature and science meet performance and safety.
Actionable Next Steps (for Readers)
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Consult your healthcare provider before starting any supplement.
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Choose omega-3 products with transparent certifications and oxidation controls.
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Incorporate omega-3-rich foods alongside supplements for holistic cardiovascular care.
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Follow MVS Pharma GmbH for research-backed health solutions.
