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Plasma Levels of EPA and DHA: Overview of the latest research by the National Library of Medicine (Plasma levels of EPA and DHA after ingestion of a single dose of EPA and DHA ethyl esters)
Summary of the Research Report
Understanding the absorption and bioavailability of Omega-3 fatty acids is essential for optimizing their health benefits. A recent study examined how plasma levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) change after ingesting a single dose of their ethyl ester forms. The findings highlight key differences in how these fatty acids are processed in the body, with EPA showing a higher plasma concentration while DHA may be more readily taken up by tissues. These insights are crucial for improving Omega-3 supplementation strategies, particularly in developing high-bioavailability formulations.
A recent study, Plasma Levels of EPA and DHA after Ingestion of a Single Dose of EPA and DHA Ethyl Esters (2024), led by Henrieke Marie-Luise Schmieta et al., analyzed the bioavailability of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ethyl esters after a single oral dose in healthy male participants.
Key Findings:
- EPA and DHA exist in different forms, including triacylglycerols (TAGs), reconstituted TAGs (rTAGs), and ethyl esters (EEs). The chemical form affects absorption and metabolism.
- Bioavailability is influenced by factors such as formulation, food matrix effects, metabolism, and dosage.
- The study used a crossover design to measure the absorption and plasma concentration kinetics of 2.2 g EPA and 2.3 g DHA over 72 hours.
- EPA plasma levels increased significantly more than DHA, with a higher peak concentration and a greater area under the curve (AUC).
- DHA may be absorbed and taken up by tissues faster than EPA, particularly by the liver, heart, and brain.
- Single-dose studies provide valuable insights but may not fully reflect long-term availability and effects.
- A separate 10-week study suggested that DHA supplementation leads to a greater increase in the Omega-3 index compared to EPA.
These findings are critical for optimizing Omega-3 supplementation and understanding the physiological roles of EPA and DHA in human health.
Application of Research Findings to MVS Omega-3: The Superior Supplement
At MVS Pharma GmbH, we integrate cutting-edge research into the formulation of our MVS Omega-3 Capsules, ensuring superior bioavailability, oxidation stability, and purity.
1. Bioavailability Optimization
- The study confirms that EPA reaches higher plasma levels more quickly than DHA, informing our formulation strategy.
- Instead of ethyl esters, we use rTG form (re-esterified triglycerides), which has higher absorption rates.
- 90% Purified Omega-3 Concentration — delivering 1440 mg total oil with 1312 mg active Omega-3s (EPA 784 mg, DHA 518 mg) per serving.
- 92% Re-esterified Triglyceride (rTG) Form — structurally identical to natural fish oil for superior absorption (1207 mg bioavailable) and full physiological compatibility.
2. Oxidation Stability
Omega-3 fatty acids are prone to oxidation, reducing efficacy. To combat this:
- We use IP-certified tocopherols as antioxidants.
- Our fish oil undergoes state-of-the-art stabilization techniques.
Oxidation markers:
- Natural Tocopherol Matrix (α, β, γ, δ) — balanced antioxidant system calibrated to protect high-purity oil without destabilization.
- Total Oxidation (TOTOX) Value: Premium production certified + Superior Encapsulation Technology + Integrity sealed Storage + Ensured Stability + Preserved Freshness of each capsule until the moment you take it. Every stage, from production to consumption, is carefully protected to ensure maximum purity and quality.
3. Pollutant Removal
We ensure stringent purification standards by applying advanced molecular distillation, removing:
- Heavy metals (Arsenic, Cadmium, Lead, Mercury)
- PCBs and dioxins (compliant with TEQ WHO standards)
- We source our Omega-3 from sustainable fisheries, guaranteeing the highest purity.
Scientific Validation
- Our Omega-3 capsules undergo independent laboratory testing, confirming high bioavailability, purity, and safety.
- Research-backed formulation integrates insights from Plasma Levels of EPA and DHA after Ingestion of a Single Dose of EPA and DHA Ethyl Esters (2024).
Conclusion
The study provides essential insights into Omega-3 kinetics, more specifically into plasma Levels of EPA and DHA. At MVS Pharma GmbH, we use the latest scientific research to help us refine our formulations. The rTG form of Omega-3 in our products ensures superior bioavailability compared to ethyl esters (EE).
By focusing on:
- Optimized bioavailability through rTG form
- Superior oxidation protection for enhanced shelf life
- Advanced purification to eliminate pollutants
We provide an industry-leading Omega-3 supplement (MVS Omega-3) that maximizes health benefits for our customers.
References
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