Hesperidin is a bioflavonoid predominantly found in citrus fruits, especially in the citrus and orange peel peels. grapefruit, lemon, and tangerines are also containing hesperidin. It’s known for its antioxidant properties, which help protect cells from damage caused by free radicals. Hesperidin was first isolated in 1828 by the French chemist Pierre-Marie-Alexis Lebreton from the white inner layer of citrus peels. This discovery marked an important step in understanding the chemistry of flavonoids. The term “hesperidin” is derived from “hesperidium.
Hesperidin Structure
- Molecular formula: C28 H34 O15
- Molecular Weight: 610.6g/mol
- IUPAC Name : (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
Various studies suggest that hesperidin may offer a wide range of health benefits like heart health, brain health, liver health, eye health, anti-inflammatory effects, immune support, etc. Meta-analyses have indicated that hesperidin supplementation may reduce cardiovascular disease (CVD) risk through mechanisms such as strengthening blood vessels and reducing inflammation. Also, It may influence lipid metabolism by decreasing LDL cholesterol levels and triglycerides while potentially increasing HDL cholesterol, contributing to a healthier lipid profile. Also, Hesperidin is well-known for its antioxidant activity. both in vitro and in vivo studies indicate that hesperidin may exert its anti-inflammatory effects by suppressing the expression of inflammatory enzymes like inducible nitric oxide synthase and cyclooxygenase-2. This suppression can lead to a reduction in inflammatory markers, further supporting its role as a natural anti-inflammatory agent. Overall, these findings suggest that hesperidin has the potential to mitigate inflammation and could be beneficial in managing inflammatory conditions.
Where is this substance found naturally?
Hesperidin is primarily found in the peels of citrus fruits, particularly oranges and lemons. Since most people don’t consume the peels, getting enough hesperidin through diet alone can be challenging. That’s why supplements are becoming popular; they offer a convenient way to increase hesperidin intake. hesperidin is available in various forms, including powdered And capsules. This makes it convenient for those looking to incorporate it into their daily routine. The powdered form allows for easier absorption and can be mixed into beverages or foods if you prefer not to take capsules. When choosing a supplement, be sure to check the dosage and any additional ingredients to ensure it meets your health goals.
Who can supplement with Hesperidin?
As always, consulting a healthcare professional before starting any new supplement is a good practice. Hesperidin has relatively low bioavailability, meaning that it is not easily absorbed by the body compared to other compounds. To improve its absorption, various strategies can be employed. For instance, combining hesperidin with ingredients like piperine can improve its bioavailability. Additionally, using fine powder formulations with the help of micro ionization can increase the surface area for absorption, making it more effective. These methods help ensure that more hesperidin reaches the systemic circulation and exerts its beneficial effects. In general, hesperidin is considered well-tolerated and safe for most people when taken as directed.
Hesperidin for Pregnant and Breastfeeding Women
In the case of Pregnant and Breastfeeding Women There is limited research on the safety of hesperidin during pregnancy and lactation, so it’s best to consult a healthcare professional before using it. Also, in the case of Individuals with Blood Disorders: Those with conditions affecting blood clotting or other blood disorders should be cautious, as hesperidin may have blood-thinning effects. Hesperidin supplements can be a beneficial addition to your diet, especially if you’re looking to enhance your overall health.
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